Drugs of Abuse Testing Reagents
Cayman Chemical UR144 NpentnoIc ACD metab 10mg
An internal standard for the quantification of CP 55940 by GC- or LC-MS intended for research and forensic applications
Cayman Chemical 5-fluoro MDMB-PICA metabolite
A BTK inhibitor (Kis 0 91 1 6 1 3 12 6 and 3 4 nM for wild-type BTK BTKC481S BTKC481R BTKT474I and BTKT474M respectively) selective for BTK over a panel of 287 additional kinases at 1 UM inhibits anti-IgM antibody-induced BTK phosphorylation in B cells (IC50 3 1 nM) as well as anti-IgM- or CD40L-induced proliferation of B cells (IC50s 1 2 and 1 4 nM respectively) reduces ankle thickness and cartilage damage in a rat model of collagen-induced arthritis
Cayman Chemical ADBICA NpentnoIc ACD metab 1mg
An aminoquinoline an inhibitor of autophagy with antimalarial anti-inflammatory anticancer and antiviral activities inhibits autophagosome-lysosome fusion in HeLa cells at 100 UM active against the chloroquine-sensitive GC03 strain of P. falciparum (IC50 29.2 nM) prevents SARS-CoV-2 infection in Vero cells (EC50 1.13 UM) but does not inhibit SARS-CoV replication in the lungs in a mouse model of SARS-CoV infection inhibits the growth of human SSC25 and CAL 27 oral squamous cell carcinoma cells (IC50s 29.9 and 17.3 UM respectively) as well as A498 SN12C RXF393 and 769-P renal cancer cells (IC50s 16 62 81 and 25 UM respectively) reduces tumor growth in a CAL 27 mouse xenograft model and a 4T1 mouse allograft model at 50 mg/kg
Cayman Chemical ADBICA NpentnoIc ACD metab 5mg
An aminoquinoline an inhibitor of autophagy with antimalarial anti-inflammatory anticancer and antiviral activities inhibits autophagosome-lysosome fusion in HeLa cells at 100 UM active against the chloroquine-sensitive GC03 strain of P. falciparum (IC50 29.2 nM) prevents SARS-CoV-2 infection in Vero cells (EC50 1.13 UM) but does not inhibit SARS-CoV replication in the lungs in a mouse model of SARS-CoV infection inhibits the growth of human SSC25 and CAL 27 oral squamous cell carcinoma cells (IC50s 29.9 and 17.3 UM respectively) as well as A498 SN12C RXF393 and 769-P renal cancer cells (IC50s 16 62 81 and 25 UM respectively) reduces tumor growth in a CAL 27 mouse xenograft model and a 4T1 mouse allograft model at 50 mg/kg
Cayman Chemical Hexafluoropropylene Oxide Dim
An inhibitor of SOICR (IC50 16.8 UM in HEK293 cells expressing RyR2R4496C) inhibits Kir2.1 late INa and ICa in isolated canine cardiomyocytes and IKr in HEK293 cells expressing hERG in hypokalaemic but not normokalaemic conditions at 1 UM an antagonist of TLR4 (IC50 32.55 UM in HEK293 cells expressing the human receptor) inhibits HCN4 in COS-7 cells expressing in HCN4 at 10 UM prevents hypokalaemia-induced ventricular arrhythmia in isolated Langendorff-perfused mouse hearts unlike carvedilol it does not reverse isoproterenol-induced increases in heart rate or decrease resting heart rate in RyR2R4496C-expressing mice
Cayman Chemical DIhomoLInolenIc AcId Metab 1ea
An inhibitor of mTOR (IC50 0 45 nM) selective for mTOR over PI3Ka (IC50 661 nM) inhibits cell growth in LNCaP cells (IC50 42 nM)
Abcam PK11195, benzodiazepine receptor antagonist, 10MG
MW 352.9 Da, Purity >99%. Antagonist at the mitochondrial (peripheral) benzodiazepine receptor (translocator protein, TSPO). Acts as a chemosensitizer of tumor cells to a wide range of chemotherapeutic agents.
The product is subject to the following: Abcam Restricted Use Statement